Oxalate issues means histamine problems

The relationship between oxalates and histamines involves complex interactions within the body's immune system.

Here's how

• Histamine is a compound released by immune cells in allergic reactions, immune responses and inflammation.

• Oxalates are naturally occurring compounds found in many plant foods, and a high intake and/or a genetic tendency can lead to the formation of oxalate crystals throughout the body causing pain and much more.

• They also activate the immune system and trigger inflammatory responses. In fact, immune cells may see oxalate crystals as foreign invaders and mount an immune response, including by releasing inflammatory mediators like cytokines.

• Oxalates can also contribute to gut inflammation and increased intestinal permeability, or leaky gut. This permeability means that toxins, bacteria, and undigested food particles can leak into the bloodstream, triggering immune responses and inflammation.

• In short, any sort of large bowel imbalance will result in inflammation and this can also lead to histamine overload because it compromises DAO activity, or the breakdown of histamines in the gut, potentially leading to an overload.

So if you already have an existing histamine intolerance, a high oxalate intake is only going to exacerbate this. It’s hard to know which comes first, but I believe this is bioindividual.

Ultimately, people with histamine intolerance and/or any inflammatory condition could benefit from reducing their intake of high-oxalate foods and addressing underlying gut health issues to help manage inflammation and any associated symptoms