Oestrogen problems - could it be your ESTROBOLOME?
An important function of your gut flora is to regulate oestrogen levels via your estrobolome, a collection of gut microbes that metabolise (transform) oestrogens. They do this by producing beta-glucuronidase, an enzyme (catalyst) that turns oestrogens into their active forms.
This active oestrogen then binds to receptors throughout your body to carry out many important physical processes involving fertility, mood and more.
But when your gut flora is imbalanced, beta-glucuronidase activity is changed, meaning your oestrogen levels can become too low or high.
For example, if your gut flora is reduced due to infections and resulting inflammation, less oestrogen and phytoestrogens are available to become the active forms your body needs. Low circulating estrogen can lead to obesity, PCOS, cognitive decline, metabolic syndrome, cardiovascular disease and osteoporosis.
Conversely, increased beta-glucuronidase production leads to higher levels of circulating oestrogens, which is linked to endometriosis and some cancers.
Excess oestrogens are mostly excreted from the body via bile and liver function in the stool. But normal liver detoxification of oestrogens can be reversed with high levels of beta-glucuronidase. Your body will then recirculate the oestrogen it intended to carry out, leading to oestrogen dominance.
How do you ensure healthy beta-glucuronidase and oestrogen activity in your gut?
You
Build a healthy and balanced gut flora by addressing any imbalances or dysbiosis by safely eradicating bacterial, parasitic, yeast/fungal and viral infections using targeted nutrients
Restore a diverse and healthy gut microbiome using real food and supplements if needed
Ensure liver and bile health using diet and nutrients
Limit stress, drugs, alcohol, sugar and refined carbs, and other toxins
Support your hormones naturally using foods and supplements In short, it’s critical to address any imbalances or dysbiosis in your gut flora to prevent or improve hormone imbalances