Our vagus nerve regulates inflammation

Our vagus nerve - the longest cranial nerve in our body - plays a crucial role in regulating inflammation through the autonomic nervous system.

It extends from the brainstem to the abdomen, supplying nerves to organs and systems along the way.

Here’s how the vagus nerve influences inflammation

• It activates the cholinergic anti-inflammatory pathway, which helps regulate the body's immune response. When stimulated, the vagus nerve releases a neurotransmitter that interacts with immune cells to reduce the production of pro-inflammatory cytokines (immune signalling molecules), decreasing inflammation

• It modulates the release of cytokines to reduce excessive inflammation and maintain immune system balance

• I's a key component of the bidirectional gut-brain axis, meaning a healthy gut microbiome supports vagus nerve function, which can help regulate systemic inflammation and overall health

Conversely, the vagus nerve can increase inflammation & contribute to disease through

• Impaired function

• Chronic stress

• Disruption in communication with the immune system

• Autoimmune disease

Stimulating the vagus nerve can help reduce inflammation and support overall health, making it a key target in managing inflammatory conditions and promoting well-being.